BiopestPeptidV1, Main, Exploration, bibRecord, 000331

Neuroprotective Effects of Dehydroepiandrosterone Sulfate Through Inhibiting Expression of Matrix Metalloproteinase-9 from Bradykinin-Challenged Astroglia.

Identifieur interne : 000331 ( Main/Exploration ); précédent : 000330; suivant : 000332

Neuroprotective Effects of Dehydroepiandrosterone Sulfate Through Inhibiting Expression of Matrix Metalloproteinase-9 from Bradykinin-Challenged Astroglia.

Auteurs : Chian-Jiun Liou [Taïwan] ; Chuen-Mao Yang [Taïwan] ; Tsong-Hai Lee [Taïwan] ; Pei-Shan Liu [Taïwan] ; Hsi-Lung Hsieh [Taïwan]

Source :

Molecular neurobiology [ 1559-1182 ] ; 2019.

RBID : pubmed:29796990

Descripteurs français

English descriptors

KwdEn :
- Animals (MeSH), Antioxidants (pharmacology), Apoptosis (drug effects), Astrocytes (drug effects), Astrocytes (enzymology), Bradykinin (adverse effects), Brain (enzymology), Cell Line (MeSH), Cell Movement (drug effects), Dehydroepiandrosterone Sulfate (pharmacology), Extracellular Signal-Regulated MAP Kinases (metabolism), Focal Adhesion Kinase 2 (metabolism), Matrix Metalloproteinase 9 (metabolism), Matrix Metalloproteinase Inhibitors (pharmacology), Models, Biological (MeSH), NADPH Oxidases (metabolism), Neuroprotective Agents (pharmacology), Phosphorylation (drug effects), Proto-Oncogene Proteins c-akt (metabolism), Rats (MeSH), Reactive Oxygen Species (metabolism), Transcription Factor AP-1 (metabolism), Up-Regulation (drug effects), src-Family Kinases (metabolism).
MESH :
- chemical , adverse effects : Bradykinin.
- chemical , metabolism : Extracellular Signal-Regulated MAP Kinases, Focal Adhesion Kinase 2, Matrix Metalloproteinase 9, NADPH Oxidases, Proto-Oncogene Proteins c-akt, Reactive Oxygen Species, Transcription Factor AP-1, src-Family Kinases.
- chemical , pharmacology : Antioxidants, Dehydroepiandrosterone Sulfate, Matrix Metalloproteinase Inhibitors, Neuroprotective Agents.
- drug effects : Apoptosis, Astrocytes, Cell Movement, Phosphorylation, Up-Regulation.
- enzymology : Astrocytes, Brain.
- Animals, Cell Line, Models, Biological, Rats.

Abstract

Dehydroepiandrosterone sulfate (DHEAS), one of the most important neuroactive steroids, is produced in the adrenals and the brain. DHEAS is believed to play a critical role in modulating different forms of cellular control, including processes associated with human neural systems. Its production rate and level in serum, adrenals, and brain gradually decrease with advancing age. The decline of DHEAS level was associated with age-related neuronal dysfunction and degeneration, most probably because the steroids protect the central nervous system (CNS) neurons against neurotoxic challenges. Moreover, increasing studies show that matrix metalloproteinases (MMPs), MMP-9 especially, are upregulated by proinflammatory mediators in the CNS disorders. The increased MMP-9 as an inflammatory biomarker of several CNS disorders that may participate in the CNS inflammation and neurodegeneration. Herein, we investigate the effects of DHEAS on brain inflammation by the model we have defined of bradykinin (BK)-induced MMP-9 expression in rat brain astrocyte (RBA) and its mechanism. The results showed that DHEAS significantly reduce MMP-9 induced by BK. Pretreatment with DHEAS can inhibit BK-stimulated phosphorylation of c-Src and PYK2. Moreover, DHEAS attenuated BK-stimulated NADPH oxidase (Nox)-derived reactive oxygen species (ROS) production, suggesting that DHEAS has an antioxidative effect. We further demonstrated that DHEAS blocked activation of ERK1/2, Akt, and c-Fos/AP-1 by BK. Finally, DHEAS decreased MMP-9-related events including RBA migration and neuronal apoptosis. The results will provide new insights into the anti-inflammatory action of DHEAS, supporting that DHEAS may have a neuroprotective effect in the improvement of the CNS disorders by reducing neuroinflammation.

DOI: 10.1007/s12035-018-1125-6
PubMed: 29796990

Affiliations:

Taïwan

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000830
to stream Main, to step Curation: 000830

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neuroprotective Effects of Dehydroepiandrosterone Sulfate Through Inhibiting Expression of Matrix Metalloproteinase-9 from Bradykinin-Challenged Astroglia.</title>
<author><name sortKey="Liou, Chian Jiun" sort="Liou, Chian Jiun" uniqKey="Liou C" first="Chian-Jiun" last="Liou">Chian-Jiun Liou</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nursing, Division of Basic Medical Sciences, Research Center for Chinese Herbal Medicine, and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Tao-Yuan, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Nursing, Division of Basic Medical Sciences, Research Center for Chinese Herbal Medicine, and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Gui-Shan, Taoyuan, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Gui-Shan, Taoyuan</wicri:regionArea>
<wicri:noRegion>Taoyuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Chuen Mao" sort="Yang, Chuen Mao" uniqKey="Yang C" first="Chuen-Mao" last="Yang">Chuen-Mao Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Physiology and Pharmacology and Health Ageing Research Center, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Physiology and Pharmacology and Health Ageing Research Center, College of Medicine, Chang Gung University, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee, Tsong Hai" sort="Lee, Tsong Hai" uniqKey="Lee T" first="Tsong-Hai" last="Lee">Tsong-Hai Lee</name>
<affiliation wicri:level="1"><nlm:affiliation>Stroke Center and Stroke Section, Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung University College of Medicine, Tao-Yuan, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Stroke Center and Stroke Section, Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung University College of Medicine, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Pei Shan" sort="Liu, Pei Shan" uniqKey="Liu P" first="Pei-Shan" last="Liu">Pei-Shan Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Soochow University, Taipei, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Microbiology, Soochow University, Taipei</wicri:regionArea>
<wicri:noRegion>Taipei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hsieh, Hsi Lung" sort="Hsieh, Hsi Lung" uniqKey="Hsieh H" first="Hsi-Lung" last="Hsieh">Hsi-Lung Hsieh</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nursing, Division of Basic Medical Sciences, Research Center for Chinese Herbal Medicine, and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Tao-Yuan, Taiwan. hlhsieh@mail.cgust.edu.tw.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Nursing, Division of Basic Medical Sciences, Research Center for Chinese Herbal Medicine, and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan. hlhsieh@mail.cgust.edu.tw.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Neurology, Chang Gung Memorial Hospital, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2019">2019</date>
<idno type="RBID">pubmed:29796990</idno>
<idno type="pmid">29796990</idno>
<idno type="doi">10.1007/s12035-018-1125-6</idno>
<idno type="wicri:Area/Main/Corpus">000830</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000830</idno>
<idno type="wicri:Area/Main/Curation">000830</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000830</idno>
<idno type="wicri:Area/Main/Exploration">000830</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Neuroprotective Effects of Dehydroepiandrosterone Sulfate Through Inhibiting Expression of Matrix Metalloproteinase-9 from Bradykinin-Challenged Astroglia.</title>
<author><name sortKey="Liou, Chian Jiun" sort="Liou, Chian Jiun" uniqKey="Liou C" first="Chian-Jiun" last="Liou">Chian-Jiun Liou</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nursing, Division of Basic Medical Sciences, Research Center for Chinese Herbal Medicine, and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Tao-Yuan, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Nursing, Division of Basic Medical Sciences, Research Center for Chinese Herbal Medicine, and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Gui-Shan, Taoyuan, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Gui-Shan, Taoyuan</wicri:regionArea>
<wicri:noRegion>Taoyuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Chuen Mao" sort="Yang, Chuen Mao" uniqKey="Yang C" first="Chuen-Mao" last="Yang">Chuen-Mao Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Physiology and Pharmacology and Health Ageing Research Center, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Physiology and Pharmacology and Health Ageing Research Center, College of Medicine, Chang Gung University, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee, Tsong Hai" sort="Lee, Tsong Hai" uniqKey="Lee T" first="Tsong-Hai" last="Lee">Tsong-Hai Lee</name>
<affiliation wicri:level="1"><nlm:affiliation>Stroke Center and Stroke Section, Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung University College of Medicine, Tao-Yuan, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Stroke Center and Stroke Section, Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung University College of Medicine, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Pei Shan" sort="Liu, Pei Shan" uniqKey="Liu P" first="Pei-Shan" last="Liu">Pei-Shan Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Soochow University, Taipei, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Microbiology, Soochow University, Taipei</wicri:regionArea>
<wicri:noRegion>Taipei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hsieh, Hsi Lung" sort="Hsieh, Hsi Lung" uniqKey="Hsieh H" first="Hsi-Lung" last="Hsieh">Hsi-Lung Hsieh</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nursing, Division of Basic Medical Sciences, Research Center for Chinese Herbal Medicine, and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Tao-Yuan, Taiwan. hlhsieh@mail.cgust.edu.tw.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Nursing, Division of Basic Medical Sciences, Research Center for Chinese Herbal Medicine, and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan. hlhsieh@mail.cgust.edu.tw.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Neurology, Chang Gung Memorial Hospital, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Molecular neurobiology</title>
<idno type="eISSN">1559-1182</idno>
<imprint><date when="2019" type="published">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Antioxidants (pharmacology)</term>
<term>Apoptosis (drug effects)</term>
<term>Astrocytes (drug effects)</term>
<term>Astrocytes (enzymology)</term>
<term>Bradykinin (adverse effects)</term>
<term>Brain (enzymology)</term>
<term>Cell Line (MeSH)</term>
<term>Cell Movement (drug effects)</term>
<term>Dehydroepiandrosterone Sulfate (pharmacology)</term>
<term>Extracellular Signal-Regulated MAP Kinases (metabolism)</term>
<term>Focal Adhesion Kinase 2 (metabolism)</term>
<term>Matrix Metalloproteinase 9 (metabolism)</term>
<term>Matrix Metalloproteinase Inhibitors (pharmacology)</term>
<term>Models, Biological (MeSH)</term>
<term>NADPH Oxidases (metabolism)</term>
<term>Neuroprotective Agents (pharmacology)</term>
<term>Phosphorylation (drug effects)</term>
<term>Proto-Oncogene Proteins c-akt (metabolism)</term>
<term>Rats (MeSH)</term>
<term>Reactive Oxygen Species (metabolism)</term>
<term>Transcription Factor AP-1 (metabolism)</term>
<term>Up-Regulation (drug effects)</term>
<term>src-Family Kinases (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Antioxydants (pharmacologie)</term>
<term>Apoptose (effets des médicaments et des substances chimiques)</term>
<term>Astrocytes (effets des médicaments et des substances chimiques)</term>
<term>Astrocytes (enzymologie)</term>
<term>Bradykinine (effets indésirables)</term>
<term>Encéphale (enzymologie)</term>
<term>Espèces réactives de l'oxygène (métabolisme)</term>
<term>Extracellular Signal-Regulated MAP Kinases (métabolisme)</term>
<term>Facteur de transcription AP-1 (métabolisme)</term>
<term>Focal adhesion kinase 2 (métabolisme)</term>
<term>Inhibiteurs de métalloprotéinases matricielles (pharmacologie)</term>
<term>Lignée cellulaire (MeSH)</term>
<term>Matrix metalloproteinase 9 (métabolisme)</term>
<term>Modèles biologiques (MeSH)</term>
<term>Mouvement cellulaire (effets des médicaments et des substances chimiques)</term>
<term>NADPH oxidase (métabolisme)</term>
<term>Neuroprotecteurs (pharmacologie)</term>
<term>Phosphorylation (effets des médicaments et des substances chimiques)</term>
<term>Protéines proto-oncogènes c-akt (métabolisme)</term>
<term>Rats (MeSH)</term>
<term>Régulation positive (effets des médicaments et des substances chimiques)</term>
<term>Sulfate de déhydroépiandrostérone (pharmacologie)</term>
<term>src-Family kinases (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Bradykinin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Extracellular Signal-Regulated MAP Kinases</term>
<term>Focal Adhesion Kinase 2</term>
<term>Matrix Metalloproteinase 9</term>
<term>NADPH Oxidases</term>
<term>Proto-Oncogene Proteins c-akt</term>
<term>Reactive Oxygen Species</term>
<term>Transcription Factor AP-1</term>
<term>src-Family Kinases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antioxidants</term>
<term>Dehydroepiandrosterone Sulfate</term>
<term>Matrix Metalloproteinase Inhibitors</term>
<term>Neuroprotective Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term>
<term>Astrocytes</term>
<term>Cell Movement</term>
<term>Phosphorylation</term>
<term>Up-Regulation</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Apoptose</term>
<term>Astrocytes</term>
<term>Mouvement cellulaire</term>
<term>Phosphorylation</term>
<term>Régulation positive</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Bradykinine</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Astrocytes</term>
<term>Encéphale</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Astrocytes</term>
<term>Brain</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Espèces réactives de l'oxygène</term>
<term>Extracellular Signal-Regulated MAP Kinases</term>
<term>Facteur de transcription AP-1</term>
<term>Focal adhesion kinase 2</term>
<term>Matrix metalloproteinase 9</term>
<term>NADPH oxidase</term>
<term>Protéines proto-oncogènes c-akt</term>
<term>src-Family kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antioxydants</term>
<term>Inhibiteurs de métalloprotéinases matricielles</term>
<term>Neuroprotecteurs</term>
<term>Sulfate de déhydroépiandrostérone</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Line</term>
<term>Models, Biological</term>
<term>Rats</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Lignée cellulaire</term>
<term>Modèles biologiques</term>
<term>Rats</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Dehydroepiandrosterone sulfate (DHEAS), one of the most important neuroactive steroids, is produced in the adrenals and the brain. DHEAS is believed to play a critical role in modulating different forms of cellular control, including processes associated with human neural systems. Its production rate and level in serum, adrenals, and brain gradually decrease with advancing age. The decline of DHEAS level was associated with age-related neuronal dysfunction and degeneration, most probably because the steroids protect the central nervous system (CNS) neurons against neurotoxic challenges. Moreover, increasing studies show that matrix metalloproteinases (MMPs), MMP-9 especially, are upregulated by proinflammatory mediators in the CNS disorders. The increased MMP-9 as an inflammatory biomarker of several CNS disorders that may participate in the CNS inflammation and neurodegeneration. Herein, we investigate the effects of DHEAS on brain inflammation by the model we have defined of bradykinin (BK)-induced MMP-9 expression in rat brain astrocyte (RBA) and its mechanism. The results showed that DHEAS significantly reduce MMP-9 induced by BK. Pretreatment with DHEAS can inhibit BK-stimulated phosphorylation of c-Src and PYK2. Moreover, DHEAS attenuated BK-stimulated NADPH oxidase (Nox)-derived reactive oxygen species (ROS) production, suggesting that DHEAS has an antioxidative effect. We further demonstrated that DHEAS blocked activation of ERK1/2, Akt, and c-Fos/AP-1 by BK. Finally, DHEAS decreased MMP-9-related events including RBA migration and neuronal apoptosis. The results will provide new insights into the anti-inflammatory action of DHEAS, supporting that DHEAS may have a neuroprotective effect in the improvement of the CNS disorders by reducing neuroinflammation.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29796990</PMID>
<DateCompleted><Year>2019</Year>
<Month>04</Month>
<Day>01</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>02</Month>
<Day>25</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1559-1182</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>56</Volume>
<Issue>1</Issue>
<PubDate><Year>2019</Year>
<Month>Jan</Month>
</PubDate>
</JournalIssue>
<Title>Molecular neurobiology</Title>
<ISOAbbreviation>Mol Neurobiol</ISOAbbreviation>
</Journal>
<ArticleTitle>Neuroprotective Effects of Dehydroepiandrosterone Sulfate Through Inhibiting Expression of Matrix Metalloproteinase-9 from Bradykinin-Challenged Astroglia.</ArticleTitle>
<Pagination><MedlinePgn>736-747</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s12035-018-1125-6</ELocationID>
<Abstract><AbstractText>Dehydroepiandrosterone sulfate (DHEAS), one of the most important neuroactive steroids, is produced in the adrenals and the brain. DHEAS is believed to play a critical role in modulating different forms of cellular control, including processes associated with human neural systems. Its production rate and level in serum, adrenals, and brain gradually decrease with advancing age. The decline of DHEAS level was associated with age-related neuronal dysfunction and degeneration, most probably because the steroids protect the central nervous system (CNS) neurons against neurotoxic challenges. Moreover, increasing studies show that matrix metalloproteinases (MMPs), MMP-9 especially, are upregulated by proinflammatory mediators in the CNS disorders. The increased MMP-9 as an inflammatory biomarker of several CNS disorders that may participate in the CNS inflammation and neurodegeneration. Herein, we investigate the effects of DHEAS on brain inflammation by the model we have defined of bradykinin (BK)-induced MMP-9 expression in rat brain astrocyte (RBA) and its mechanism. The results showed that DHEAS significantly reduce MMP-9 induced by BK. Pretreatment with DHEAS can inhibit BK-stimulated phosphorylation of c-Src and PYK2. Moreover, DHEAS attenuated BK-stimulated NADPH oxidase (Nox)-derived reactive oxygen species (ROS) production, suggesting that DHEAS has an antioxidative effect. We further demonstrated that DHEAS blocked activation of ERK1/2, Akt, and c-Fos/AP-1 by BK. Finally, DHEAS decreased MMP-9-related events including RBA migration and neuronal apoptosis. The results will provide new insights into the anti-inflammatory action of DHEAS, supporting that DHEAS may have a neuroprotective effect in the improvement of the CNS disorders by reducing neuroinflammation.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liou</LastName>
<ForeName>Chian-Jiun</ForeName>
<Initials>CJ</Initials>
<AffiliationInfo><Affiliation>Department of Nursing, Division of Basic Medical Sciences, Research Center for Chinese Herbal Medicine, and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Tao-Yuan, Taiwan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Gui-Shan, Taoyuan, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Chuen-Mao</ForeName>
<Initials>CM</Initials>
<AffiliationInfo><Affiliation>Department of Physiology and Pharmacology and Health Ageing Research Center, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Tsong-Hai</ForeName>
<Initials>TH</Initials>
<AffiliationInfo><Affiliation>Stroke Center and Stroke Section, Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung University College of Medicine, Tao-Yuan, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Pei-Shan</ForeName>
<Initials>PS</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, Soochow University, Taipei, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hsieh</LastName>
<ForeName>Hsi-Lung</ForeName>
<Initials>HL</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0001-8302-2472</Identifier>
<AffiliationInfo><Affiliation>Department of Nursing, Division of Basic Medical Sciences, Research Center for Chinese Herbal Medicine, and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Tao-Yuan, Taiwan. hlhsieh@mail.cgust.edu.tw.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Neurology, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan. hlhsieh@mail.cgust.edu.tw.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>NSC102-2320-B-255-005-MY3</GrantID>
<Agency>Ministry of Science and Technology, Taiwan</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>MOST106-2320-B-255-005</GrantID>
<Agency>Ministry of Science and Technology, Taiwan</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>CMRPF1C0193, CMRPF3D0033, CMRPF1F0131, and CMRPF1F0132</GrantID>
<Agency>Chang Gung Medical Foundation</Agency>
<Country></Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>05</Month>
<Day>23</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Mol Neurobiol</MedlineTA>
<NlmUniqueID>8900963</NlmUniqueID>
<ISSNLinking>0893-7648</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D061965">Matrix Metalloproteinase Inhibitors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018696">Neuroprotective Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D017382">Reactive Oxygen Species</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018808">Transcription Factor AP-1</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>57B09Q7FJR</RegistryNumber>
<NameOfSubstance UI="D019314">Dehydroepiandrosterone Sulfate</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.6.3.-</RegistryNumber>
<NameOfSubstance UI="D019255">NADPH Oxidases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.10.2</RegistryNumber>
<NameOfSubstance UI="D051418">Focal Adhesion Kinase 2</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.10.2</RegistryNumber>
<NameOfSubstance UI="D019061">src-Family Kinases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="D051057">Proto-Oncogene Proteins c-akt</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.24</RegistryNumber>
<NameOfSubstance UI="D048049">Extracellular Signal-Regulated MAP Kinases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.4.24.35</RegistryNumber>
<NameOfSubstance UI="D020780">Matrix Metalloproteinase 9</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>S8TIM42R2W</RegistryNumber>
<NameOfSubstance UI="D001920">Bradykinin</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017209" MajorTopicYN="N">Apoptosis</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001253" MajorTopicYN="N">Astrocytes</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001920" MajorTopicYN="N">Bradykinin</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002465" MajorTopicYN="N">Cell Movement</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019314" MajorTopicYN="N">Dehydroepiandrosterone Sulfate</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D048049" MajorTopicYN="N">Extracellular Signal-Regulated MAP Kinases</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051418" MajorTopicYN="N">Focal Adhesion Kinase 2</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020780" MajorTopicYN="N">Matrix Metalloproteinase 9</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D061965" MajorTopicYN="N">Matrix Metalloproteinase Inhibitors</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008954" MajorTopicYN="N">Models, Biological</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019255" MajorTopicYN="N">NADPH Oxidases</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018696" MajorTopicYN="N">Neuroprotective Agents</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010766" MajorTopicYN="N">Phosphorylation</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051057" MajorTopicYN="N">Proto-Oncogene Proteins c-akt</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017382" MajorTopicYN="N">Reactive Oxygen Species</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018808" MajorTopicYN="N">Transcription Factor AP-1</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015854" MajorTopicYN="N">Up-Regulation</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019061" MajorTopicYN="N">src-Family Kinases</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Anti-inflammation</Keyword>
<Keyword MajorTopicYN="N">Bradykinin</Keyword>
<Keyword MajorTopicYN="N">Brain astrocytes</Keyword>
<Keyword MajorTopicYN="N">Dehydroepiandrosterone sulfate</Keyword>
<Keyword MajorTopicYN="N">Matrix metalloproteinase-9</Keyword>
<Keyword MajorTopicYN="N">Neuroprotection</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year>
<Month>01</Month>
<Day>13</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2018</Year>
<Month>05</Month>
<Day>11</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2018</Year>
<Month>5</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2019</Year>
<Month>4</Month>
<Day>2</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2018</Year>
<Month>5</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">29796990</ArticleId>
<ArticleId IdType="doi">10.1007/s12035-018-1125-6</ArticleId>
<ArticleId IdType="pii">10.1007/s12035-018-1125-6</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Cell Signal. 1999 Jan;11(1):1-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10206339</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Free Radic Biol Med. 1999 May;26(9-10):1346-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10381209</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurochem. 1999 Oct;73(4):1461-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10501190</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Neuroendocrinol. 2000 Jan;21(1):1-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10662535</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurotrauma. 2000 Oct;17(10):871-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11063054</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cereb Blood Flow Metab. 2001 Jan;21(1):2-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11149664</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biol Chem. 2001 Jan;382(1):49-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11258671</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Neurosci. 2001 Jul;2(7):502-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11433375</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FASEB J. 2001 Sep;15(11):1953-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11532975</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurosci Res. 2001 Sep;41(1):33-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11535291</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Brain Res Mol Brain Res. 2002 Jan 31;98(1-2):58-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11834296</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Yao Xue Xue Bao. 1998 Jun;33(6):413-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12016909</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cytokines Cell Mol Ther. 2002 Mar;7(1):1-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12171246</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Glia. 2002 Sep;39(3):279-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12203394</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Circ Res. 2002 Nov 29;91(11):1031-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12456489</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Glia. 2003 Jan;41(1):15-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12465042</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chem Res Toxicol. 1992 Mar-Apr;5(2):227-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1322737</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2004 Jan 9;279(2):1415-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14578353</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Signal. 2004 Oct;16(10):1163-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15240011</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Free Radic Biol Med. 2004 Sep 15;37(6):768-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15304253</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuropharmacology. 2006 Mar;50(3):380-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16364377</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurochem. 2006 Jun;97(6):1634-58</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16805774</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1583-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16987013</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Free Radic Biol Med. 2006 Oct 15;41(8):1304-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17015177</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann N Y Acad Sci. 2006 Nov;1088:139-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17192562</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Glia. 2007 May;55(7):758-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17352382</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2007 Nov 15;179(10):7001-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17982091</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurosci Res. 2008 May 1;86(6):1361-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18189315</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Glia. 2008 Apr 15;56(6):619-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18240315</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurochem. 2008 May;105(4):1499-512</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18315570</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Mol Med. 2008 Nov;14(11):495-502</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18929509</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Pharmacol Exp Ther. 2009 Aug;330(2):494-501</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19420298</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Gerontol Geriatr. 2009;49 Suppl 1:173-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19836631</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neuroinflammation. 2010 Dec 06;7:88</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21134288</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Steroids. 2012 Feb;77(3):233-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22155530</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Steroids. 2012 Feb;77(3):260-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22182832</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neuroinflammation. 2012 Apr 16;9:68</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22507553</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antiviral Res. 2012 Jul;95(1):37-48</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22584352</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Commun Signal. 2012 Nov 23;10(1):35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23176293</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Neurobiol. 2013 Jun;47(3):1020-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23307413</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biomed Res Int. 2013;2013:484613</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24455696</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cell Physiol. 2014 Dec;229(12):2088-105</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24825463</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncotarget. 2015 Sep 22;6(28):24675-89</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26360782</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Neurobiol. 2016 Nov;53(9):5995-6005</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26526842</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Biochem Cell Biol. 2016 Jan;70:126-39</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26643608</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Med Rep. 2017 Jan;15(1):169-179</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27959401</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Circ Res. 1995 Nov;77(5):863-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7554139</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Stroke. 1993 Apr;24(4):571-5; discussion 575-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7682018</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurochem. 1995 Apr;64(4):1513-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7891077</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncogene. 1993 Feb;8(2):395-405</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8426746</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann N Y Acad Sci. 1995 Dec 29;774:121-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8597452</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Endocrinol Metab. 1996 Sep;81(9):3147-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8784058</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuroimmunomodulation. 1996 Sep-Oct;3(5):285-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9218249</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Neurosci. 1998 Feb;21(2):75-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9498303</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Taïwan</li>
</country>
</list>
<tree><country name="Taïwan"><noRegion><name sortKey="Liou, Chian Jiun" sort="Liou, Chian Jiun" uniqKey="Liou C" first="Chian-Jiun" last="Liou">Chian-Jiun Liou</name>
</noRegion>
<name sortKey="Hsieh, Hsi Lung" sort="Hsieh, Hsi Lung" uniqKey="Hsieh H" first="Hsi-Lung" last="Hsieh">Hsi-Lung Hsieh</name>
<name sortKey="Hsieh, Hsi Lung" sort="Hsieh, Hsi Lung" uniqKey="Hsieh H" first="Hsi-Lung" last="Hsieh">Hsi-Lung Hsieh</name>
<name sortKey="Lee, Tsong Hai" sort="Lee, Tsong Hai" uniqKey="Lee T" first="Tsong-Hai" last="Lee">Tsong-Hai Lee</name>
<name sortKey="Liou, Chian Jiun" sort="Liou, Chian Jiun" uniqKey="Liou C" first="Chian-Jiun" last="Liou">Chian-Jiun Liou</name>
<name sortKey="Liu, Pei Shan" sort="Liu, Pei Shan" uniqKey="Liu P" first="Pei-Shan" last="Liu">Pei-Shan Liu</name>
<name sortKey="Yang, Chuen Mao" sort="Yang, Chuen Mao" uniqKey="Yang C" first="Chuen-Mao" last="Yang">Chuen-Mao Yang</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/BiopestPeptidV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000331 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000331 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    BiopestPeptidV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:29796990
   |texte=   Neuroprotective Effects of Dehydroepiandrosterone Sulfate Through Inhibiting Expression of Matrix Metalloproteinase-9 from Bradykinin-Challenged Astroglia.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:29796990" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a BiopestPeptidV1

This area was generated with Dilib version V0.6.38.
Data generation: Thu Nov 19 19:22:35 2020. Site generation: Thu Nov 19 19:33:26 2020

	Serveur d'exploration sur les peptides biopesticides
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les peptides biopesticides

Neuroprotective Effects of Dehydroepiandrosterone Sulfate Through Inhibiting Expression of Matrix Metalloproteinase-9 from Bradykinin-Challenged Astroglia.

Neuroprotective Effects of Dehydroepiandrosterone Sulfate Through Inhibiting Expression of Matrix Metalloproteinase-9 from Bradykinin-Challenged Astroglia.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki